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. 2019 Jul 2;8:e47145. doi: 10.7554/eLife.47145

Figure 6. Distribution of dyneins in the axoneme.

Figure 6.

(A) Schematic view of the positions the dynein heavy chain tails dock on the A-tubule of the microtubule doublet (green) in the 96 nm axonemal repeat, based on previous structural data on C. reinhardtii and Sea urchin sperm flagella (Bui et al., 2008; Lin and Nicastro, 2018; Nicastro et al., 2006). Heavy chains are named according to the C. reinhardtii nomenclature, and the human orthologues are linked. Heavy chains are colour coded based on whether they possess a MTBD flap (Red) or not (beige). (B) Orthogonal view of A, now looking down the flagella. Links between the inner and outer dynein arms and the exact protofilament of the adjacent doublet has also been established by structural work (Song et al., 2018). The position of the tails on tubule A1 positions the MTBDs on tubule B2. We note each of protofilaments 7 to 10 on tubule B2 are contacted by flap-containing dynein MTBDs.