Table 3.
Hematological data for rat in the 28 days oral administration of KGC-03-PS
| Dose (mg/kg) | ||||
|---|---|---|---|---|
|
| ||||
| 0 (n = 6) | 500 (n = 6) | 1000 (n = 6) | 2000 (n = 6) | |
| Male | ||||
| WBC | 8.33 ± 1.40 | 8.44 ± 1.29 | 8.71 ± 1.81 | 9.96 ± 1.75 |
| RBC | 7.96 ± 0.36 | 8.66 ± 0.48 | 8.92 ± 0.39* | 8.86 ± 0.73 |
| Hb | 17.62 ± 0.57 | 18.67 ± 1.46 | 19.48 ± 1.60 | 19.62 ± 1.46 |
| HCT | 43.0 ± 1.2 | 46.2 ± 3.4 | 47.7 ± 3.8 | 47.8 ± 2.8 |
| MCV | 54.2 ± 1.1 | 52.8 ± 0.5 | 52.9 ± 1.6 | 53.0 ± 0.6 |
| MCH | 22.2 ± 1.1 | 21.4 ± 0.7 | 21.4 ± 0.3 | 21.9 ± 0.8 |
| MCHC | 40.1 ± 1.7 | 40.5 ± 1.0 | 40.6 ± 1.1 | 41.2 ± 1.2 |
| PLT | 761 ± 53 | 658 ± 96 | 653 ± 81 | 708 ± 76 |
| Female | ||||
| WBC | 6.08 ± 0.95 | 7.45 ± 1.40 | 7.48 ± 1.96 | 6.90 ± 0.96 |
| RBC | 7.47 ± 0.37 | 7.43 ± 0.28 | 8.12 ± 0.45 | 8.24 ± 0.62* |
| Hb | 15.9 ± 0.7 | 16.2 ± 0.5 | 16.7 ± 0.8 | 17.6 ± 1.1* |
| HCT | 42.6 ± 1.5 | 41.9 ± 2.6 | 46. 7 ± 1.9 | 47.8 ± 3.5* |
| MCV | 57.2 ± 2.3 | 56.4 ± 1.9 | 57.5 ± 1.6 | 57.0 ± 1.0 |
| MCH | 21.3 ± 0.9 | 21.9 ± 0.5 | 20.6 ± 0.6 | 21.4 ± 0.6 |
| MCHC | 37.2 ± 1.0 | 38.9 ± 1.5 | 35.8 ± 1.5 | 37.6 ± 0.7 |
| PLT | 915 ± 48 | 905 ± 35 | 898 ± 95 | 774 ± 109* |
WBC (103/μL), White blood cells; RBC (106/μL), Red blood cells; Hb (g/dL), Hemoglobin; HCT (%), Hematocrits; MCV (fL), Mean corpuscular volume; MCH (pg), Mean corpuscular hemoglobin; MCHC (g/dL), Mean corpuscular hemoglobin concentration; PLT (103/μL), Platelet.
Data were expressed as mean ± SD.
*
Significant difference vs. control (p < 0.05).