Table 1:
Overall descriptive characteristics of all Clinical Pharmacology Quality Assurance Proficiency Testing reported concentrations (RC) from 11 individual clinical pharmacology laboratories for 8 antiretroviral analytes during 13 rounds conducted from 2010 through 2016.
| # RCs by CPL (%Acceptable) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ARV (range, ng/mL) | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | RC Score (% Acceptable) |
ARV/Round Score (% Satisfactory) |
| ATV (150–12000) | 65 (100) | 65 (100) | 60 (98) | 65 (89) | 65 (97) | 30 (100) | 45 (100) | 55 (98) | 55 (95) | 505 (97) | 101 (97) | ||
| DRV (350–12000) | 65 (98) | 65 (100) | 60 (100) | 50 (100) | 65 (100) | 50 (96) | 45 (100) | 55 (100) | 65 (98) | 520 (99) | 104 (99) | ||
| EFV (230–20000) | 65 (100) | 65 (100) | 55 (95) | 65 (100) | 65 (100) | 65 (100) | 45 (100) | 60 (98) | 50 (100) | 50 (92) | 585 (99) | 117 (98) | |
| FTC (25–4500) | 65 (100) | 65 (100) | 65 (94) | 25 (100) | 30 (100) | 20 (70) | 65 (100) | 60 (88) | 15 (100) | 410 (96) | 82 (93) | ||
| LPV (220–24000) | 65 (100) | 65 (100) | 60 (98) | 65 (100) | 65 (97) | 65 (100) | 45 (100) | 50 (80) | 50 (98) | 55 (93) | 585 (97) | 117 (96) | |
| NVP (225–12000) | 65 (100) | 65 (100) | 55 (91) | 65 (100) | 65 (89) | 50 (96) | 60 (90) | 54 (96) | 479 (95) | 96 (96) | |||
| RTV (75–5800) | 30 (67) | 65 (100) | 60 (98) | 65 (97) | 55 (84) | 65 (98) | 45 (100) | 60 (93) | 65 (97) | 45 (100) | 555 (95) | 111 (95) | |
| TFV (30–600) | 65 (97) | 65 (100) | 65 (95) | 25 (100) | 60 (98) | 35 (100) | 65 (100) | 60 (92) | 15 (100) | 15 (100) | 470 (98) | 94 (96) | |
| RC Score (% Acceptable) |
485 (97) | 520 (100) | 130 (95) | 400 (97) | 465 (98) | 400 (94) | 360 (99) | 355 (100) | 460 (93) | 315 (98) | 219 (95) | ||
| ARV/Round Score (% Satisfactory) |
97 (97) | 104 (100) | 26 (92) | 80 (98) | 93 (97) | 80 (93) | 72 (97) | 71 (100) | 92 (89) | 63 (98) | 44 (95) | 4109(97) | 822(96) |
CPL: clinical pharmacology laboratory, ARV: antiretroviral, RC: reported concentration, ATV: atazanavir, DRV: darunavir, EFV: efavirenz, FTC: emtricitabine, LPV: lopinavir, NVP: nevirapine, RTV: ritonavir, and TFV: tenofovir