Table 1.
Properties of hydrogels and associated evaluation parameters at each formulation stage.
| Development Stage | Property | Evaluation Parameters |
|---|---|---|
| Pre-formulation | Solubility | • pKa |
| • pH range solubility | ||
| • Temperature range solubility | ||
| • Dissolution | ||
| Stability | • Payload at varying temperatures and pH | |
| • Monomers and crosslinkers at varying temperatures and pH | ||
| • Drug-polymer interaction | ||
| Drug crystallinity | ||
| Drug polymorphism | ||
| Formulation | Mechanical properties | • Rheology |
| • Compression/Extension | ||
| • Crosslinking density evaluation | ||
| Morphology | • Porosity | |
| • Topography | ||
| Swelling | ||
| Drug content | ||
| Drug release | • Dissolution | |
| Biosafety | • In vitro and in vivo biocompatibility | |
| Bioactivity | ||
| Manufacturing | Stability | • Post-sterilization |
| • Shelf-life | ||
| • Bulk stability | ||
| Administration | • Tool compatibility | |
| • Pre-injection mixing |