Table 1:
Patient characteristics at enrollment summarized overall and by ICU admission*
| Characteristics | Overall (N=3673) |
No ICU Admissions (N=3301) |
1 or more ICU admissions (N=372) |
|---|---|---|---|
| Age at enrollment, years | 73 [66, 80] | 73 [65, 79] | 77 [73, 82] |
| Age ≥ 65 years at enrollment | 2859 (78%) | 2502 (76%) | 357 (96%) |
| Sex | |||
| Male | 1897 (52%) | 1666 (50%) | 231 (62%) |
| Female | 1776 (48%) | 1635 (50%) | 141 (38%) |
| BMI, kg/m2, n=3632 | 27.7 [24.9, 31.2] | 27.7 [24.8, 31.1] | 28.3 [25.0, 32.2] |
| BMI ≥ 30, n=3632 | 1178 (32%) | 1045 (32%) | 133 (36%) |
| Ever diagnosed alcohol problem, n=3646 | 164 (4%) | 145 (4%) | 19 (5%) |
| APOE E4 genotype, n=3632 | 1024 (28%) | 924 (28%) | 100 (27%) |
| Midlife diabetes, n=3672 | 307 (8%) | 281 (9%) | 26 (7%) |
| Midlife hypertension, n=3672 | 1478 (40%) | 1316 (40%) | 162 (44%) |
| Midlife dyslipidemia, n=3672 | 1831 (50%) | 1645 (50%) | 186 (50%) |
| Charlson comorbidity index | |||
| 1–2 | 2049 (56%) | 1905 (58%) | 144 (39%) |
| 3+ | 1624 (44%) | 1396 (42%) | 228 (61%) |
| Education, years | |||
| Less than 12 years | 189 (5%) | 161 (5%) | 28 (8%) |
| 12 years | 1025 (28%) | 903 (27%) | 122 (33%) |
| 13–15 years | 1016 (28%) | 915 (28%) | 101 (27%) |
| 16 years and above | 1443 (39%) | 1322 (40%) | 121 (33%) |
| Marital status, n=3668 | |||
| Single | 447 (12%) | 422 (13%) | 25 (7%) |
| Married | 2630 (72%) | 2356 (71%) | 274 (74%) |
| Widowed | 591 (16%) | 518 (16%) | 73 (20%) |
| Smoking status, n=3672 | |||
| Never | 1961 (53%) | 1801 (55%) | 160 (43%) |
| Former | 1545 (42%) | 1346 (41%) | 199 (53%) |
| Current | 166 (5%) | 153 (5%) | 13 (3%) |
| Baseline Cognitive status | |||
| Cognitively unimpaired | 3304 (90%) | 2973 (90%) | 331 (89%) |
| Mild cognitive impairment | 369 (10%) | 328 (10%) | 41 (11%) |
| Baseline Cognitive z-score, overall | 0.7 [−0.0, 1.4] | 0.7 [−0.0, 1.4] | 0.4 [−0.2, 1.0] |
| among Age ≤ 69 | 1.4 [0.9, 1.9] | 1.4 [0.9, 1.9] | 1.1 [0.5, 1.6] |
| among 70 ≤ Age ≤ 79 | 0.5 [−0.0, 1.1] | 0.5 [−0.0, 1.1] | 0.5 [−0.0, 1.1] |
| among 80 ≤ Age | −0.1 [−0.8, 0.5] | −0.1 [−0.9, 0.5] | 0.0 [−0.6, 0.7] |
*
Midlife is defined as age < 65 years. For patients who enrolled prior to age 65, midlife values reflect status at baseline. For variables with missing information, total number with complete data is summarized. *Baseline cognitive z-score is obtained on the first MCSA visit. Values are median [25th, 75th percentile] or n (percentage).