Brain areas with altered fALFF before acupuncture between two groups. (A) areas in blue indicated brain areas where fALFF was significantly decreased while areas in red indicated brain areas where fALFF was significantly increased, sagittal view, Alphasim corrected, P<0.05; (B) red sphere indicated areas where fALFF was significantly changed, sagittal view, Alphasim corrected, P<0.05; (C) time-course of signal change within 4 different brain areas between smoking group and non-smoking group. fALFF, fractional amplitude of low-frequency fluctuation.