MRI-PDFF (A) and R2* (B) maps of a 45-year-old woman with NAFLD (liver steatosis grade 2, iron grade 1, fibrosis stage 2 and inflammation grade 1) determined by histologic validation. Four largest-fit ROIs (one per the right lobe anterior, right lobe posterior, left lobe medial, and left lobe lateral segment) were manually positioned in the homogeneous liver parenchyma at the level of the right main portal vein. MRI-PDFF and R2* values were directly derived by drawing ROI on the related parameter maps. NAFLD, nonalcoholic fatty liver disease; ROI, region of interest; PDFF, proton density fat fraction.