Table 3:

Outcome differences by vascular invasion status, stage III (n=458)

Stage III patients	No invasion n = 275	IMVI only n = 26	EMVI only n = 112	Both n = 45	P-value
Lymphatic invasion	124 (45.1%)	19 (73.1%)	86 (76.8%)	39 (86.7%)	<0.001
Adjuvant chemotherapy	197 (71.6%)	20 (76.9%)	83 (74.1%)	32 (71.1%)	0.909
Locoregional recurrence	35 (12.7%)	6 (23.1%)	29 (25.9%)	8 (17.8%)	0.015
Distant recurrence	49 (17.8%)	6 (23.1%)	49 (43.8%)	14 (31.1%)	<0.001
Disease-free survival					<0.001
K-M 3-year estimate | NAR	81.0% | 153	78.5% | 18	52.3% | 37	61.4% | 18
K-M 5-year estimate | NAR	76.6% | 90	70.7% | 9	46.1% | 28	55.8% | 10
Overall survival					0.009
K-M 3-year estimate | NAR	79.3% | 173	68.0% | 17	67.7% | 62	55.7% | 22
K-M 5-year estimate | NAR	68.0% | 100	60.4% | 8	55.2% | 32	44.3% | 10
Colon cancer specific survival					<0.001
K-M 3-year estimate | NAR	91.3% | 173	78.3% | 18	78.8% | 62	69.6% | 22
K-M 5-year estimate | NAR	85.5% | 106	78.3% | 18	66.8% | 32	55.4% | 10

Abbreviations: IMVI: Intramural Vascular Invasion; EMVI: Extramural Vascular Invasion; K-M: Kaplan Meier. NAR: Number at risk Survival estimates calculated by log-rank