Table 4:
Cox Proportional Regression models of Disease-free survival and Disease-specific survival
| Disease-free survival | Colon cancer specific survival | |||
|---|---|---|---|---|
| Variable | HR (95% CI) | P-value | HR (95% CI) | P-value |
| Age | 1.00 (0.99–1.01) | 0.949 | 1.01 (0.99–1.02) | 0.172 |
| ASA-score, III-IV | 1.36 (1.00–1.83) | 0.048 | 1.46 (1.01–2.10) | 0.044 |
| Vascular invasion | ||||
| Absent | Reference | Reference | ||
| IMVI only | 0.74 (0.34–1.59) | 0.436 | 1.53 (0.72–3.25) | 0.270 |
| EMVI only | 2.07 (1.46–2.93) | <0.001 | 1.67 (1.06–2.64) | 0.027 |
| IMVI + EMVI | 1.52 (0.88–2.63) | 0.135 | 2.39 (1.31–4.36) | 0.005 |
| T4 tumors | 1.50 (1.09–2.06) | 0.012 | 2.14 (1.46–3.13) | <0.001 |
| Lymph-node disease | 1.56 (1.12–2.16) | 0.008 | 1.61 (1.04–2.48) | 0.033 |
| Tumor location | ||||
| Right-sided | Reference | Reference | ||
| Transverse | 0.84 (0.45–1.57) | 0.581 | 1.24 (0.60–2.56) | 0.561 |
| Left sided | 1.60 (0.99–2.57) | 0.052 | 1.58 (0.86–2.91) | 0.144 |
| (Recto)Sigmoid | 1.38 (0.97–1.95) | 0.076 | 1.75 (1.13–2.73) | 0.013 |
| Multiple | 2.09 (0.83–5.25) | 0.116 | 2.41 (0.73–7.91) | 0.148 |
| Lymphatic invasion | 1.30 (0.93–1.83) | 0.130 | 1.48 (0.95–2.30) | 0.080 |
| High grade | 1.64 (1.18–2.28) | 0.003 | 1.77 (1.21–2.59) | 0.003 |
| Perineural invasion | 1.72 (1.23–2.41) | 0.002 | 1.59 (1.05–2.42) | 0.028 |
| MSI-high versus stable/low | 0.69 (0.40–1.17) | 0.167 | 0.82 (0.41–1.61) | 0.555 |
| Bowel obstruction | 1.87 (1.18–2.96) | 0.008 | 2.40 (1.43–4.03) | 0.001 |
| R0-resection | 0.61 (0.34–1.12) | 0.112 | 0.42 (0.23–0.77) | 0.005 |
| Adjuvant chemotherapy | 1.16 (0.81–1.68) | 0.421 | 0.95 (0.57–1.60) | 0.852 |
Abbreviations: ASA: American Society of Anesthesiologists; IMVI: Intramural Vascular Invasion; EMVI: Extramural Vascular Invasion; HR: Hazard Ratio; CI: Confidence Interval