Table 4. Diagnostic capability of tested biomarkers for bacterial infection in acute pediatric diarrhea (n=62).

Biomarker	AUC (%)	Cut-off values	TP (No.)	FN (No.)	TN (No.)	FP (No.)	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Accuracy (%)
CRP and lactoferrin (µg/mL)	0.838 (0.723–0.920)	13.7, 22.8	13	5	42	2	72.2 (46.5–90.3)	95.5 (84.5–99.4)	86.7 (58.9–98.4)	89.4 (76.6–96.5)	88.7
CRP and fecal occult blood (µg/mL)	0.780 (0.650–0.870)	13.7, 100	10	8	44	0	55.6 (30.8–78.5)	100 (92.0–100)	100 (69.2–100)	84.6 (72.0–93.1)	87.1
CRP (mg/L)	0.792 (0.670–0.884)	13.7	15	3	30	14	83.3 (58.6–96.4)	68.2 (52.4–81.4)	51.7 (32.2–70.9)	90.9 (75.3–98.2)	72.6
Lactoferrin (µg/mL)	0.739 (0.611–0.842)	22.8	14	4	31	13	77.8 (52.4–93.6)	70.5 (54.8–83.2)	51.8 (31.6–71.6)	88.6 (72.9–96.9)	72.6
Fecal occult blood (ng/mL)	0.715 (0.586–0.822)	100	11	7	36	8	61.1 (35.7–82.7)	81.8 (67.3–91.8)	57.9 (33.1–80.1)	83.7 (69.0–93.3)	75.8
MPO (ng/mL)	0.685 (0.555–0.797)	4.14	14	4	25	19	77.8 (52.4–93.6)	56.8 (41.0–71.7)	42.4 (25.2–61.1)	86.2 (68.0–96.2)	62.9
Calprotectin (µg/g)	0.675 (0.544–0.788)	74.0	17	1	17	27	94.4 (72.7–99.9)	38.6 (24.4–54.5)	38.6 (24.1–54.8)	94.4 (72.2–99.9)	54.8
ESR (mm/hr)	0.674 (0.542–0.789)	25	11	7	32	12	61.1 (35.7–82.7)	72.7 (57.2–85.0)	47.8 (26.8–69.4)	82.1 (66.5–92.5)	71.0
Fecal leukocyte (/HPF)	0.643 (0.511–0.760)	1	8	11	37	7	44.4 (21.5–69.2)	84.1 (69.9–93.4)	53.3 (26.2–79.1)	78.7 (64.1–89.4)	72.6

Values are presented as number only, data (95% confidence interval), or percent only.

AUC: area under the curve, TP: true positive, FN: false negative, TN: true negative, FP: false positive, PPV: positive predictive value, NPV: negative predictive value, CRP: C-reactive protein, MPO: myeloperoxidase, ESR: erythrocyte sedimentation rate, HPF: high power field.