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Important KAT2 binding residues for glycyrrhizic acid (GL), glycyrrhetinic acid (GA) and carbenoxolone (CBX).
| Interactions | KYN | GL | GA | CBX |
|---|---|---|---|---|
| Hydrogen bond |
Asn202(B), Arg399(B) |
Ser77(A) |
Gly39(A) Tyr142(B) |
Ser77(A) |
| Hydrophobic effects | Leu40(A) Tyr74(A) |
Leu40(A) Tyr74(A) Pro76(A) Gln73(A) |
Leu40(A) Tyr74(A) Pro76(A) Gln73(A) |
Leu40(A) Tyr74(A) Pro76(A) Gln73(A) |
| Stacking | Tyr74(A) | Tyr74(A) | Tyr74(A) | Tyr74(A) |
