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. 2019 Jul 15;9:10160. doi: 10.1038/s41598-019-46331-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Changes in skeletal muscle weight and muscle fiber cross-sectional area. (A) Weight of the tibialis anterior (TA) muscle was unchanged, (B) but muscle fiber cross-sectional area (CSA) of the TA was reduced by 22% in MCT mice compared to sham, but unaltered in MCT + NI. (B) Weight of the EDL muscle was unchanged, but (D) skeletal muscle fiber CSA of the EDL was reduced by 29% in the MCT mice compared to sham and preserved in the MCT + NI group(*p < 0.05). (E) Weight of the soleus muscle was similar in all groups and (F) skeletal muscle fiber CSA was also unchanged.