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. 2019 Jul 15;10:3117. doi: 10.1038/s41467-019-11074-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Proposed DNA unwinding mechanism by the MCM complex. The figure depicts one step of the translocation cycle (see also Supplementary Movie 4). The hexameric ring pulls two nucleotides of the cyan strand through the central pore to provide two base-pairs of unwinding (72° rotation and 7.76 Å translation for idealized B-form DNA). Each subunit is uniquely colored in transparent cartoon, and the two DNA strands are in cyan and magenta spheres. Every 12th DNA nucleotide is colored white to help show strand motion. In this orientation, the ring exerts a downward force on the cyan strand (translocation) and an upward normal force on the magenta strand (exclusion)