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. 2019 Jul 15;9:10176. doi: 10.1038/s41598-019-46671-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Semi-thin sections of the colon of adult male mice (Toluidine blue stain, 1000x). (A,B: Control group A) Apical parts of the mucosa; columnar cells (arrows) and many goblet cells (g) that may open into the lumen. (B) Basal parts of the crypts lined with many goblet cells (g), muscularis mucosa (mm). (C,D: DSS group C) Apical parts of mucosa with mucosal ulcers (arrows). (D) Basal parts of the crypts; few goblet cells (g), diffuse inflammatory cell infiltrations (arrow heads). (E,F: DSS+ AuNPs group E) Apical parts of the mucosa, columnar cells (arrows), many goblet cells (g). (F) Basal parts of the crypts, many goblet cells (g).