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. 2019 Jul 15;9:10176. doi: 10.1038/s41598-019-46671-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Sections of the colon of adult male mice. (A–C) Mallory’s trichrome-stained sections (200x); collagen fibers (arrows). (A) Control group showing few collagen fibers, (B) DSS group showing numerous collagen fibers, (C) DSS+ AuNPs group showing some collagen fibers. (D–F) Alcian blue-stained sections (200x); goblet cells (g). (D) Control group with abundant goblet cells, (E) DSS group with few goblet cells, (F) DSS+ AuNPs group with many goblet cells. (G–I) Immune histochemical-stained sections for IL-17A (400x); brown positive cytoplasmic reactions (arrows). (G) Control group showing reactions in few cells, (H) DSS group showing reactions in many cells, (I): DSS+ AuNPs group showing reactions in some cells.