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. 2019 Jul 15;9:10176. doi: 10.1038/s41598-019-46671-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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An electron micrograph of ultrathin sections in the colon of adult male mice. (A–D: DSS group. A) Intraepithelial infiltrating plasma cell with cartwheel-shaped nucleus (n), rough endoplasmic reticulum (RER), nucleus of columnar cell (N). (B) An eosinophil with bilobed nucleus (N) and specific granules (arrows). (C) Infiltrating neutrophil with segmented nucleus (N), a goblet cell with mucous granules (gr). (D–G: DSS+ AuNPs group. D) Columnar cells with abundant microvilli (MV) and mitochondria (M), a part of goblet cell (g). An inset: magnification of the boxed part showing electron dense AuNPs (arrows) in the cytoplasm and within a lysosome (E) Columnar cells with abundant microvilli (MV), normal cell junction (bifid arrows), a lysosome containing electron dense AuNPs (arrows). (F) Goblet cells with mucous granules (gr), abundant rough endoplasmic reticulum (RER) and basal nuclei (N). (G) Columnar cells (arrows), a thin core of lamina propria (Lp), smooth muscle cells of muscularis mucosa (sm).