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. 2019 Jul 15;9:10183. doi: 10.1038/s41598-019-46617-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Summary of the integrated mechanism for nucleosome reorganization by Mid-pAID of FACT. Histone proteins and DNA in nucleosomes are indicated by different colors as follows: H2B (red), H2A (yellow), H3 (blue), H4 (green), and DNA (light sea green). Both Mid and pAID are colored magenta. RNAPII is colored dodger blue. The blue box represents the αN helix of H3. Disordered regions of proteins are indicated by colored strings. The red open circles labeled with P indicate the phosphorylation sites.