Fig. 4.

Lipoprotein [Lp(a)] and progression of aortic valve stenosis, as well as the incidence of aortic valve replacement

A, both arrows indicate the predicted progression of preexisting mild-to-moderate calcific aortic valve stenosis (CAVS) on echocardiography in meters/second/year in the ASTRONOMER trial. The gray arrow shows the progression of aortic valve stenosis among patients whose Lp(a) < 58.6 mg/dL; the orange arrow shows the progression of aortic valve stenosis among patients whose Lp(a) ≥ 58.6 mg/dL. B, the event-free survival curve divided into two groups based on the Lp(a) level. The gray line represents patients whose Lp(a) < 58.6 mg/dL; the orange arrow represents patients whose Lp(a) ≥ 58.6 mg/dL.