Table 6. Estimate mean value (95% CI) for the association between sdLDL-C and cardiovascular biomarkers in participants without CAD excluded current smokers (n = 489).
sdLDL-C, mg/dL | |||||
---|---|---|---|---|---|
< 21.0 | 21.0–29.7 | 29.8–42.4 | > 42.4 | p-valueb | |
n = 150 | n = 149 | n = 147 | n = 148 | ||
hs-CRP, mg/dL | 0.13 (0.11, 0.14) | 0.15 (0.13, 0.16) | 0.15 (0.14, 0.16) | 0.27 (0.23, 0.30) | 0.0142 |
White blood cells, 103/µL | 5.62 (5.52, 5.72) | 5.92 (5.78, 6.06) | 5.89 (5.83, 5.96) | 6.58 (6.46, 6.70)‡ | < 0.0001 |
Neutrophils,103/µL | 3.18 (3.12, 3.24) | 3.38 (3.29, 3.47) | 3.31 (3.26, 3.36) | 3.80 (3.71, 3.89)† | 0.0003 |
Lymphocytes, 103/µL | 1.94 (1.90, 1.97) | 2.06 (2.01, 2.10) | 2.07 (2.04, 2.10) | 2.21 (2.17, 2.25)* | 0.0004 |
Monocytes, 103/µL | 0.276 (0.273, 0.279) | 0.306 (0.299, 0.314) | 0.285 (0.279, 0.290) | 0.316 (0.308, 0.323) | 0.0509 |
Fibrinogen, mg/dL | 256.9 (254.6, 259.1) | 264.0 (261.0, 267.1) | 262.1 (260.2, 264.1) | 276.1 (272.9, 279.3)* | 0.004 |
D-dimer, mg/L | 0.324 (0.316, 0.332) | 0.309 (0.306, 0.313) | 0.359 (0.329, 0.389) | 0.30 (0.284, 0.316) | 0.9891 |
Adiponectin, ng/mL | 2573.0 (2354, 2792) | 1993.5 (1861, 2126) | 1888.1 (1714, 2063)* | 1467.2 (1394, 1540)† | < 0.0001 |
Glu AUC ,mg/dL | 218.8 (214.7, 223.0) | 234.8 (231.8, 237.8) | 254.1 (250.4, 257.8)‡ | 282.0 (277.6, 286.5)‡ | < 0.0001 |
Hemoglobin A1c, % | 5.48 (5.45, 5.52) | 5.53 (5.51, 5.55) | 5.54 (5.52, 5.56) | 5.95 (5.90, 6.00)‡ | < 0.0001 |
Red blood cells, 106/µL | 5.03 (4.99, 5.07) | 5.24 (5.18, 5.30)* | 5.18 (5.15, 5.21) | 5.26 (5.23, 5.29) | 0.0086 |
Hematocrit,% | 44.54 (44.20, 44.88) | 45.59 (45.23, 45.95) | 45.92 (45.69, 46.15)* | 46.53 (46.29, 46.78)‡ | < 0.0001 |
Data in tables were derived from the least square mean (95% CI) after adjusting for age, gender, BMI, hypertension, household income, smoking and drinking habits.
Significance in asterisk of quartiles 2, 3, 4 indicate p-value compared with quartile 1 after multiple linear regression analyses.
p-value for trend were modeled according to median value of each quartile.
p < 0.05,
p < 0.01,
p < 0.001
Abbreviations: hs-CRP, high-sensitivity C-reactive protein; Glu AUC, glucose levels area under curve after OGTT