Table 2. The top five results of functional enrichment analyses of down-regulated DEGs ranked by P-value.
| Term | Count | Gene | P-value |
|---|---|---|---|
| GO-BPs | |||
| GO:0007155∼cell adhesion | 30 | CTNNAL1, IGFBP7, ITGA10, SPOCK1, POSTN, CDH2, ITGBL1, ISLR, VCAM1, WISP1, ROBO1, FAT1, FAP, COL8A1, LAMB1, THBS2, DPT, PTPRK, MPDZ, PODXL, COL15A1, PPFIBP1, SSPN, TPBG, TNFAIP6, OMD, CX3CR1, MYH10, CDH11, AOC3 | 3.32E-15 |
| GO:0030198∼extracellular matrix organization | 15 | PDGFA, LUM, COL3A1, FBN1, ITGA10, POSTN, SPARC, ECM2, COL5A2, VCAM1, EGFLAM, BGN, COL1A2, LAMB1, COL8A1 | 1.44E-08 |
| GO:0030199∼collagen fibril organization | 7 | SFRP2, LUM, COL3A1, COL1A2, FOXC1, COL5A2, DPT | 2.61E-06 |
| GO:0001501∼skeletal system development | 10 | AEBP1, COL3A1, FBN1, COL1A2, POSTN, FOXC1, EXT1, COL5A2, PRELP, CDH11 | 1.17E-05 |
| GO:0001503∼ossification | 8 | MGP, LRRC17, FOXC1, SPARC, EXT1, COL5A2, CDH11, TWIST1 | 1.77E-05 |
| KEGG pathways | |||
| hsa04510:Focal adhesion | 11 | VEGFC, CAV2, CCND1, PDGFA, COL3A1, COL1A2, ITGA10, LAMB1, THBS2, COL5A2, MYLK | 7.82E-06 |
| hsa04611:Platelet activation | 7 | GNAI1, COL3A1, COL1A2, GUCY1A3, COL5A2, MYLK, F2R | 7.86E-04 |
| hsa04512:ECM-receptor interaction | 6 | COL3A1, COL1A2, ITGA10, LAMB1, THBS2, COL5A2 | 8.27E-04 |
| hsa04151:PI3K-Akt signaling pathway | 10 | VEGFC, CCND1, PDGFA, COL3A1, COL1A2, ITGA10, LAMB1, THBS2, COL5A2, F2R | 0.002384 |
| hsa04974:Protein digestion and absorption | 5 | COL21A1, COL3A1, COL1A2, COL15A1, COL5A2 | 0.00656 |
GO, Gene Ontology; BP, biological process; KEGG, Kyoto Encyclopedia of Genes and Genomes; DEGs, differentially expressed genes.