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. 2019 Jul 9;7:479. doi: 10.3389/fchem.2019.00479

Figure 5.

Figure 5

Effect of BDS-I[1-8] fragment on KV3.4 currents in NGF-differentiated PC-12 cells under control condition and exposed to Aβ1−42. (A) Representative traces of KV3.4 currents recorded in NGF-differentiated PC-12 cells under control condition and exposed to 100 nM of BDS-I[1-8] (top); representative traces of KV3.4 currents recorded in NGF-differentiated PC-12 cells exposed to Aβ1−42 oligomers (5 μM for 24 h) in the absence and in the presence of BDS-I[1-8] fragment (30 min of pre-treatment before adding Aβ1−42 oligomers) (bottom). For each group, traces show KV3.4 currents elicited by depolarizing steps of increasing voltages from −80 to +40 mV (20 mV of increments), preceded by a conditioning prepulse at −100 mV. (B) Quantification of KV3.4 current densities, at the peak of the depolirizing pulse (+40 mV) represented in A. Values are expressed as percentage mean±SEM from 6 to 10 cells per experimental group of 3 independent experimental sessions. Statistical comparisons between groups were performed by one-way ANOVA followed by Newman-Keuls' test; **p < 0.01 vs. control; ∧ p < 0.01 vs. Aβ1−42.