Table 1.
Studies reporting the structures of fibrillar protein assemblies from patients with various neurodegenerative diseases other than prion diseases.
| Neurodegenerative disease (assembled protein) | Structural method | Tissue source | Reference |
|---|---|---|---|
| Alzheimer’s disease (AD; Amyloid-β) | Negative stain EM | Brain from patients with AD | Paravastu et al. (2009) |
| Alzheimer’s disease (Amyloid-β) | Negative stain EM | Brain from patients with AD | Lu et al. (2013) |
| Alzheimer’s disease (Tau) | Cryo-EM | Brain from patients with AD | Fitzpatrick et al. (2017) |
| Pick’s disease (Tau) | Cryo-EM | Brain from patients with Pick’s disease | Falcon et al. (2018) |
| Chronic traumatic encephalopathy (CTE; Tau) | Cryo-EM | Brain from patients with CTE | Falcon et al. (2019) |
| Parkinson’s disease/dementia with Lewy bodies (α-synuclein) | Negative stain EM | Brain from patients with dementia with Lewy bodies | Spillantini et al. (1998) |
| Amyotrophic lateral sclerosis (ALS; SOD1) | Negative stain EM | Spinal cord from patients with familial ALS | Kato et al. (1997, 2000) |
| Frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral sclerosis (TDP-43) | Negative stain EM | Brain from patients with FTLD-U and ALS | Lin and Dickson (2008) |
| Frontotemporal lobar degeneration (TDP-43) | Negative stain EM | Brain from patients with FTLD with TDP-43 proteinopathy | Thorpe et al. (2008) |
| Amyotrophic lateral sclerosis and frontotemporal lobar degeneration (TDP-43) | Negative stain EM | Brain from patients with ALS and FTLD-with TDP-43 proteinopathy | Nonaka et al. (2013) |
| Frontotemporal lobar degeneration (TDP-43) | Negative stain EM | Brain from patients with FTLD with TDP-43 proteinopathy | Laferrière et al. (2019) |