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. 2019 Jul 9;13:296. doi: 10.3389/fncel.2019.00296

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Copyright © 2019 Karikari, Nagel, Grainger, Clarke-Bland, Crowe, Hill and Moffat.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic illustration of the N279K and V337M mutations in tau. The K18 fragment used in this study was constructed based on the full-length human brain tau isoform (2N4R; htau40). The N279K mutation is located in the alternatively spliced second repeat region (R2), specifically within the hexapeptide motif at the start of R2 (PHF6^∗; gray). The V337M mutation can be found at the start of the fourth repeat domain, and falls within the third hexapeptide motif (PHF6^∗∗; second gray region).