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. 2019 Jul 9;13:296. doi: 10.3389/fncel.2019.00296

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Copyright © 2019 Karikari, Nagel, Grainger, Clarke-Bland, Crowe, Hill and Moffat.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Internalized tau K18 oligomers in hiPSC-derived neurons co-localize with endogenous tau bearing the HT7 (¹⁵⁹PPGQK¹⁶³) mid-region epitope. Extracellularly applied oligomers of tau K18-WT (A), K18-V337M (B), and K18-N279K (C) oligomers internalized in hiPSC-derived neurons co-localized with endogenous tau in the soma and the neurites. White arrowheads show sites of co-localization. Scale bar = 10 μm for all images. Figure extension in Supplementary Figures S8A–C.