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Internalized tau K18 oligomers do not induce LDH-dependent cytotoxicity in SH-SY5Y cells. Increasing concentrations of oligomeric tau K18 variants were applied to SH-SY5Y cells for 72 h, and the cells analyzed for LDH release. We found no significant difference in LDH release between the controls (buffer only or maximum control) and the tau K18 variants at the concentrations studied (n = 3 each).
