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. 2019 Jul 9;10:434. doi: 10.3389/fendo.2019.00434

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Copyright © 2019 Chen, Xu, Wu, Chen, Fang, Han, Yu, Huang, Peng and Ge.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of RES on the behavioral performance of NAFLD rats in the OFT, EPM, FST, and SPT. The data are presented as the mean ± SEM, with five rats in the CON + RES group and eight rats in each of the other groups. In the OFT, there was no significant difference among groups with respect to the total distance traveled (A), the distance traveled in the center (B), or the frequency of rearing or grooming (C). There was no change in performance in the EPM (D) or FST (E) among the groups. Compared with those of the control and CON + RES groups, the SPI of the rats in NAFLD model group was reduced (F), and this reduction could be reversed by treatment with RES, STG, or FLX (F).