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. 2019 Jul 15;9:10244. doi: 10.1038/s41598-019-46124-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Figure (A) and (B) shows loss of SDHB protein expression on immunohistochemical analysis of the primary wtGIST tumour in case #001 and #003 respectively. In Figure (B) SDHB expression is preserved in adjacent normal tissue as highlighted by the red arrow. Figure (C) shows a pulmonary chondroma in case #021 as demonstrated by the white arrow and Figure (D) demonstrates the histology of a pulmonary chondroma from case #004, with evidence of normal collapsed lung tissue illustrated by the black arrow and chondrocytes in the tumor marked by the red arrow.