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. 2019 Jul 9;13:587. doi: 10.3389/fnins.2019.00587

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Copyright © 2019 Sorby-Adams, Leonard, Elms, Marian, Hoving, Yassi, Vink, Thornton and Turner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SP and caveolin-1 immunoreactivity in sham (S) and post-stroke animals at 1 (1), 2 (2), 3 (3), 4 (4), 5 (5), 6 (6), and 7 days (7) post-stoke. There was no identifiable immunoreactivity of SP or caveolin-1 in sham animals (S). Low levels of SP immunoreactivity were seen perivascularly at 1–4 days post-stroke. At 5 and 6 days following transient MCAO, there was an increase in SP seen in the perivascular tissue of the ischemic penumbra in the affected hemisphere. This increase in SP was concordant with an increase in caveolin-1 immunoreactivity perivascularly, which was most evident at 5–6 days. Arrows indicate increased immunoreactivity of SP and cav-1 seen surrounding vessels. Scale bar 100 μm, 40× magnification.