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. 2019 Jul 9;10:1499. doi: 10.3389/fmicb.2019.01499

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Copyright © 2019 Alviz-Gazitua, Fuentes-Alburquenque, Rojas, Turner, Guiliani and Seeger.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Domain-level depiction of c-di-GMP metabolism proteins from C. metallidurans CH34. Proteins with GGDEF/EAL domains that are catalytically active according to bioinformatic analyses are shown. (A) Diguanylate cyclases. (B) Phosphodiesterases. (C) Hybrid GGDEF/EAL proteins.