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. 2019 Jul 9;9:562. doi: 10.3389/fonc.2019.00562

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Copyright © 2019 Neves, de Carvalho, da Silva, Rodrigues, Bomfim, Dias, Sales, Rocha, Soares, Batista and Bezerra.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of ruthenium complexes containing heterocyclic thioamidates on the morphology of HepG2 cells, as determined by light-scattering features detected by flow cytometry after 24 (A,C) and 48 (B,D) h of incubation. The negative control (CTL) was treated with the vehicle (0.2% DMSO) that was used to solubilize and dilute the complexes, and doxorubicin (DOX, 2 μM) was used as the positive control. Data are presented as the mean ± S.E.M. of three independent experiments that were performed in duplicate. *P < 0.05 compared with the negative control, as determined by ANOVA followed by the Student-Newman-Keuls test. Ten thousand events were evaluated per experiment, and cellular debris was omitted from the analysis.