Table 1. The association of PCAT1 polymorphisms and CRC risk.
| SNP* | Genotype | PHWE | Controls (%) | CRC | CRC vs CON | Colon cancer vs CON | Rectal cancer vs CON | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| All (%) | Colon cancer (%) | Rectal cancer (%) | P† value | OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | ||||
| rs1902432 | TT | 0.557 | 170 (34.07) | 160 (36.87) | 90 (39.47) | 70 (33.98) | 1 (Ref) | 1 (Ref) | ||||
| TC | 237 (47.49) | 208 (47.92) | 111 (48.68) | 97 (47.09) | 0.830 | 0.97 (0.71–1.31) | 0.638 | 0.92 (0.64–1.31) | 0.874 | 1.03 (0.71–1.51) | ||
| CC | 92 (18.44) | 66 (15.21) | 27 (11.85) | 39 (18.93) | 0.163 | 0.74 (0.49–1.13) | 0.030 | 0.57 (0.33–0.94) | 0.916 | 0.97 (0.59–1.60) | ||
| CC+TC vs TT | 0.519 | 0.91 (0.6–1.22) | 0.252 | 0.82 (0.58–1.15) | 0.893 | 1.03 (0.72–1.47) | ||||||
| CC vs TT+TC | 0.158 | 0.76 (0.53–1.11) | 0.030 | 0.59 (0.36–0.95) | 0.897 | 0.97 (0.63–1.51) | ||||||
| C vs T | 0.229 | 0.89 (0.73–1.08) | 0.051 | 0.79 (0.62–1.00) | 0.970 | 1.01 (0.79–1.28) | ||||||
| rs4573233 | GG | 0.688 | 331 (66.73) | 274 (63.57) | 141 (61.84) | 133 (65.52) | 1 (Ref) | 1 (Ref) | ||||
| GA | 150 (30.24) | 138 (32.02) | 77 (33.77) | 61 (30.05) | 0.615 | 1.08 (0.80–1.47) | 0.394 | 1.17 (0.82–1.67) | 0.947 | 0.99 (0.68–1.44) | ||
| AA | 15 (3.03) | 19 (4.41) | 10 (4.39) | 9 (4.93) | 0.273 | 1.54 (0.71–3.32) | 0.333 | 1.55 (0.64–3.76) | 0.365 | 1.53 (0.61–3.80) | ||
| AA+GA vs GG | 0.442 | 1.12 (0.84–1.50) | 0.297 | 1.20 (0.85–1.69) | 0.850 | 1.04 (0.72–1.49) | ||||||
| AA vs GG+GA | 0.294 | 1.50 (0.71–3.18) | 0.400 | 1.46 (0.61–3.48) | 0.344 | 1.54 (0.63–3.78) | ||||||
| A vs G | 0.312 | 1.14 (0.89–1.46) | 0.243 | 1.19 (0.89–1.60) | 0.631 | 1.08 (0.79–1.47) | ||||||
| rs710885 | TT | 0.122 | 446 (88.32) | 370 (85.65) | 195 (85.53) | 175 (85.78) | 1 (Ref) | 1 (Ref) | ||||
| TG | 55 (10.89) | 57 (13.19) | 32 (14.04) | 25 (12.25) | 0.090 | 1.45 (0.94–2.21) | 0.100 | 1.51 (0.92–2.48) | 0.250 | 1.37 (0.80–2.32) | ||
| GG | 4 (0.79) | 5 (1.16) | 1 (0.43) | 4 (1.97) | 0.506 | 1.62 (0.39–6.76) | 0.673 | 0.62 (0.06–5.88) | 0.176 | 2.84 (0.63–12.93) | ||
| GG+TG vs TT | 0.072 | 1.46 (0.97–2.21) | 0.133 | 1.45 (0.89–2.35) | 0.132 | 1.48 (0.89–2.45) | ||||||
| GG vs TT+TG | 0.543 | 1.56 (0.37–6.54) | 0.647 | 0.59 (0.06–5.65) | 0.193 | 2.74 (0.60–12.51) | ||||||
| G vs T | 0.065 | 1.44 (0.98–2.11) | 0.192 | 1.35 (0.86–2.14) | 0.071 | 1.53 (0.96–2.44) | ||||||
| rs785005 | GG | 0.629 | 221 (44.92) | 199 (45.96) | 97 (42.73) | 102 (49.51) | 1 (Ref) | 1 (Ref) | ||||
| GA | 221 (44.92) | 190 (43.88) | 102 (44.94) | 88 (42.72) | 0.579 | 0.92 (0.68–1.24) | 0.982 | 1.00 (0.70–1.43) | 0.334 | 0.84 (0.58–1.20) | ||
| AA | 50 (10.16) | 44 (10.16) | 28 (12.33) | 16 (7.77) | 0.763 | 0.93 (0.57–1.52) | 0.509 | 1.21 (0.69–2.11) | 0.198 | 0.65 (0.34–1.25) | ||
| AA+GA vs GG | 0.570 | 0.92 (0.70–1.22) | 0.808 | 1.04 (0.75–1.46) | 0.216 | 0.80 (0.57–1.14) | ||||||
| AA vs GG+GA | 0.896 | 0.97 (0.61–1.54) | 0.474 | 1.21 (0.71–2.04) | 0.292 | 0.72 (0.39–1.33) | ||||||
| A vs G | 0.627 | 0.95 (0.77–1.17) | 0.607 | 1.07 (0.83–1.37) | 0.159 | 0.83 (0.64–1.08) | ||||||
| rs2632159 | TT | 0.991 | 357 (70.55) | 281 (65.20) | 142 (62.83) | 139 (67.81) | 1 (Ref) | 1 (Ref) | ||||
| TC | 136 (26.88) | 130 (30.16) | 77 (34.07) | 53 (25.85) | 0.129 | 1.27 (0.93–1.73) | 0.033 | 1.48 (1.03–2.12) | 0.789 | 1.06 (0.71–1.56) | ||
| CC | 13 (2.57) | 20 (4.64) | 7 (3.10) | 13 (6.34) | 0.026 | 2.38 (1.11–5.09) | 0.304 | 1.67 (0.63–4.41) | 0.008 | 3.12 (1.34–7.23) | ||
| CC+TC vs TT | 0.040 | 1.37 (1.01–1.84) | 0.022 | 1.51 (1.06–2.14) | 0.286 | 1.22 (0.85–1.77) | ||||||
| CC vs TT+TC | 0.041 | 2.19 (1.03–4.64) | 0.445 | 1.46 (0.56–3.81) | 0.009 | 3.03 (1.32–6.94) | ||||||
| C vs T | 0.013 | 1.39 (1.07–1.79) | 0.023 | 1.42 (1.05–1.92) | 0.061 | 1.35 (0.99–1.85) | ||||||
Terms in bold represent significant results (P<0.05). PHWE = P value for Hardy–Weinberg Equilibrium.Abbreviations: CRC, colorectal cancer; NA, not available. *, the sort order was according to the SNP location in its genes from 5′ starting to 3′ ends. †, P value was calculated by adjusted age and gender.