Table 2. Association of lnRNA-PCAT1 polymorphisms with the CRC susceptibility stratified by host characteristics.
| SNP | Variable | Genotype | CON | CRC | CRC vs CON | Colon cancer vs CON | Rectal cancer vs CON | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| All | Colon cancer | Rectal cancer | P* value | OR (95% CI) | P* value | OR (95% CI) | P* value | OR (95% CI) | ||||
| rs1902432 | Gender | |||||||||||
| Male | TT | 77 | 90 | 44 | 46 | 1 (Ref) | 1 (Ref) | 1 (Ref) | ||||
| TC | 106 | 113 | 56 | 57 | 0.733 | 0.93 (0.59–1.45) | 0.813 | 0.94 (0.55–1.59) | 0.733 | 0.91 (0.54–1.54) | ||
| CC | 45 | 47 | 19 | 28 | 0.558 | 0.85 (0.48–1.49) | 0.311 | 0.70 (0.35–1.40) | 0.961 | 0.98 (0.52–1.87) | ||
| Female | TT | 93 | 70 | 46 | 24 | 1 (Ref) | 1 (Ref) | 1 (Ref) | ||||
| TC | 131 | 95 | 55 | 40 | 0.973 | 0.99 (0.65–1.51) | 0.608 | 0.88 (0.54–1.43) | 0.531 | 1.20 (0.68–2.14) | ||
| CC | 47 | 19 | 8 | 11 | 0.109 | 0.59 (0.31–1.13) | 0.028 | 0.38 (0.16–0.90) | 0.908 | 0.95 (0.43–2.14) | ||
| Age | ||||||||||||
| ≦60 | TT | 120 | 80 | 40 | 40 | 1 (Ref) | 1 (Ref) | 1 (Ref) | ||||
| TC | 173 | 106 | 59 | 47 | 0.679 | 0.92 (0.64–1.34) | 0.925 | 1.02 (0.64–1.63) | 0.436 | 0.83 (0.51–1.34) | ||
| CC | 75 | 32 | 14 | 18 | 0.073 | 0.63 (0.38–1.04) | 0.088 | 0.56 (0.28–1.09) | 0.279 | 0.71 (0.38–1.33) | ||
| >60 | TT | 50 | 80 | 50 | 30 | 1 (Ref) | 1 (Ref) | 1 (Ref) | ||||
| TC | 64 | 102 | 52 | 50 | 0.830 | 0.95 (0.58–1.54) | 0.399 | 0.79 (0.46–1.36) | 0.495 | 1.24 (0.67–2.26) | ||
| CC | 17 | 34 | 13 | 21 | 0.867 | 1.06 (0.52–2.15) | 0.388 | 0.69 (0.30–1.60) | 0.206 | 1.70 (0.75–3.84) | ||
| rs4573233 | Gender | |||||||||||
| Male | GG | 152 | 160 | 77 | 83 | 1 (Ref) | 1 (Ref) | 1 (Ref) | ||||
| GA | 66 | 79 | 37 | 42 | 0.815 | 1.06 (0.67–1.65) | 0.933 | 1.02 (0.60–1.75) | 0.759 | 1.08 (0.65–1.82) | ||
| AA | 5 | 11 | 5 | 6 | 0.090 | 2.90 (0.85–9.93) | 0.162 | 2.69 (0.67–10.73) | 0.102 | 3.14 (0.80–12.33) | ||
| Female | GG | 10 | 8 | 64 | 50 | 1 (Ref) | 1 (Ref) | 1 (Ref) | ||||
| GA | 84 | 59 | 40 | 19 | 0.659 | 1.10 (0.72–1.67) | 0.248 | 1.33 (0.82–2.16) | 0.485 | 0.81 (0.45–1.47) | ||
| AA | 179 | 114 | 5 | 3 | 0.890 | 1.07 (0.39–2.96) | 0.818 | 1.15 (0.35–3.72) | 0.961 | 0.97 (0.25–3.75) | ||
| Age | ||||||||||||
| ≦60 | GG | 254 | 142 | 75 | 67 | 1 (Ref) | 1 (Ref) | 1 (Ref) | ||||
| GA | 104 | 67 | 35 | 32 | 0.450 | 1.15 (0.80–1.67) | 0.579 | 1.14 (0.72–1.81) | 0.525 | 1.17 (0.72–1.89) | ||
| AA | 10 | 7 | 3 | 4 | 0.659 | 1.25 (0.47–3.35) | 0.985 | 1.01 (0.27–3.78) | 0.495 | 1.51 (0.46–4.98) | ||
| >60 | GG | 77 | 132 | 66 | 66 | 1 (Ref) | 1 (Ref) | 1 (Ref) | ||||
| GA | 46 | 71 | 42 | 29 | 0.749 | 0.92 (0.57–1.50) | 0.792 | 1.08 (0.63–1.85) | 0.343 | 0.75 (0.41–1.36) | ||
| AA | 5 | 12 | 7 | 5 | 0.352 | 1.71 (0.55–5.28) | 0.315 | 1.87 (0.55–6.32) | 0.561 | 1.50 (0.39–5.81) | ||
| rs710885 | Gender | |||||||||||
| Male | TT | 210 | 217 | 102 | 115 | 1 (Ref) | 1 (Ref) | 1 (Ref) | ||||
| TG | 19 | 31 | 18 | 13 | 0.033 | 2.09 (1.06–4.11) | 0.013 | 2.60 (1.22–5.55) | 0.222 | 1.65 (0.74–3.68) | ||
| GG | 1 | 3 | 0 | 3 | 0.506 | 2.20 (0.22–22.60) | NA | NA | 0.233 | 4.12 (0.40–42.27) | ||
| Female | TT | 236 | 153 | 93 | 60 | 1 (Ref) | 1 (Ref) | 1 (Ref) | ||||
| TG | 36 | 26 | 14 | 12 | 0.657 | 1.14 (0.65–1.99) | 0.985 | 1.01 (0.51–.99) | 0.438 | 1.33 (0.65–2.74) | ||
| GG | 3 | 2 | 1 | 1 | 0.862 | 1.18 (0.18–7.62) | 0.986 | 0.98 (0.10–10.10) | 0.741 | 1.48 (0.15–15.10) | ||
| Age | ||||||||||||
| ≦60 | TT | 327 | 181 | 95 | 86 | 1 (Ref) | 1 (Ref) | 1 (Ref) | ||||
| TG | 40 | 33 | 18 | 15 | 0.106 | 1.51 (0.92–2.47) | 0.152 | 1.55 (0.85–2.84) | 0.254 | 1.45 (0.77–2.76) | ||
| GG | 4 | 1 | 0 | 1 | 0.491 | 0.46 (0.05–4.17) | NA | NA | 0.997 | 1.01 (0.11–9.20) | ||
| >60 | TT | 119 | 189 | 100 | 89 | 1 (Ref) | 1 (Ref) | 1 (Ref) | ||||
| TG | 15 | 24 | 14 | 10 | 0.677 | 1.16 (0.57–2.37) | 0.607 | 1.23 (0.56–2.71) | 0.878 | 1.07 (0.44–2.60) | ||
| GG | 0 | 4 | 1 | 3 | NA | NA | NA | NA | NA | NA | ||
| rs785005 | Gender | |||||||||||
| Male | GG | 99 | 121 | 53 | 68 | 1 (Ref) | 1 (Ref) | 1 (Ref) | ||||
| GA | 96 | 107 | 54 | 53 | 0.528 | 0.87 (0.56–1.35) | 0.997 | 1.00 (0.60–1.68) | 0.298 | 0.77 (0.46–1.27) | ||
| AA | 28 | 24 | 13 | 11 | 0.395 | 0.73 (0.35–1.51) | 0.824 | 0.91 (0.39–2.12) | 0.240 | 0.60 (0.26–1.41) | ||
| Female | GG | 122 | 78 | 44 | 34 | 1 (Ref) | 1 (Ref) | 1 (Ref) | ||||
| GA | 125 | 83 | 48 | 35 | 0.936 | 0.98 (0.65–1.48) | 0.989 | 1.00 (0.61–1.64) | 0.876 | 0.96 (0.56–1.65) | ||
| AA | 22 | 20 | 15 | 5 | 0.458 | 1.30 (0.65–2.59) | 0.157 | 1.73 (0.81–3.70) | 0.576 | 0.74 (0.26–2.14) | ||
| Age | ||||||||||||
| ≦60 | GG | 169 | 96 | 48 | 48 | 1 (Ref) | 1 (Ref) | 1 (Ref) | ||||
| GA | 160 | 98 | 51 | 47 | 0.655 | 1.09 (0.76–1.55) | 0.607 | 1.13 (0.72–1.76) | 0.855 | 1.04 (0.66–1.65) | ||
| AA | 52 | 103 | 14 | 10 | 0.709 | 1.12 (0.63–1.97) | 0.413 | 1.34 (0.67–2.68) | 0.794 | 0.90 (0.42–1.95) | ||
| >60 | GG | 52 | 103 | 49 | 54 | 1 (Ref) | 1 (Ref) | 1 (Ref) | ||||
| GA | 61 | 92 | 51 | 41 | 0.320 | 0.78 (0.48–1.27) | 0.706 | 0.90 (0.52–1.56) | 0.160 | 0.66 (0.37–1.18) | ||
| AA | 12 | 20 | 14 | 6 | 0.880 | 094 (0.40–2.20) | 0.552 | 1.32 (0.53–3.27) | 0.259 | 0.53 (0.17–1.61) | ||
| rs2632159 | Gender | |||||||||||
| Male | TT | 169 | 166 | 75 | 91 | 1 (Ref) | ||||||
| TC | 56 | 71 | 41 | 30 | 0.396 | 1.22 (0.77–1.94) | 0.100 | 1.56 (0.92–2.65) | 0.829 | 0.94 (0.54–1.64) | ||
| CC | 6 | 12 | 2 | 10 | 0.081 | 2.64 (0.89–7.82) | 0.978 | 0.98 (0.18–5.23) | 0.017 | 3.97 (1.28–12.25) | ||
| Female | TT | 188 | 115 | 67 | 48 | 1 (Ref) | ||||||
| TC | 80 | 59 | 36 | 23 | 0.269 | 1.27 (0.83–1.93) | 0.250 | 1.34 (0.82–2.20) | 0.580 | 1.17 (0.67–2.07) | ||
| CC | 7 | 8 | 5 | 3 | 0.164 | 2.14 (0.73–6.23) | 0.167 | 2.35 (0.70–7.92) | 0.385 | 1.86 (0.46–7.61) | ||
| Age | ||||||||||||
| ≦60 | TT | 262 | 140 | 71 | 69 | 1 (Ref) | 1 (Ref) | 1 (Ref) | ||||
| TC | 97 | 65 | 37 | 28 | 0.185 | 1.73 (0.77–3.90) | 0.139 | 1.42 (0.89–2.25) | 0.679 | 1.11 (0.68–1.83) | ||
| CC | 13 | 12 | 5 | 7 | 0.218 | 1.27 (0.87–1.84) | 0.522 | 1.42 (0.49–4.11) | 0.140 | 2.06 (0.79–5.39) | ||
| >60 | TT | 95 | 141 | 71 | 70 | 1 (Ref) | 1 (Ref) | 1 (Ref) | ||||
| TC | 39 | 65 | 40 | 25 | NA | NA | 0.240 | 1.39 (0.80–2.40) | 0.706 | 0.89 (0.48–1.65) | ||
| CC | 0 | 8 | 2 | 6 | 0.563 | 1.16 (0.71–1.89) | NA | NA | NA | NA | ||
Terms in bold represent significant results (P<0.05).
*using Logistic Regression adjusted by the two factors of gender and age. Abbreviations: CON, controls; CRC, colorectal cancer. NA, not available.