Table 4. Epistatic effect of pairwise interacting factors for PCAT1 on the risks of CRC.

Interacted pairwise SNPs	Comparison	Subset	CRC vs CON		Colon cancer vs CON		Rectal cancer vs CON
			P value	OR (95% CI)	P value	OR (95% CI)	P value	OR (95% CI)
rs1902432 interacted with rs2632159	rs1902432 CC vs TT+TC	rs2632159 CC	NA	NA	NA	NA	NA	NA
		rs2632159 TT+TC	0.196	0.78 (0.54–1.14)	0.025	0.57 (0.35–0.93)	0.871	1.04 (0.67–1.62)
	rs2632159 CC vs TT+TC	rs1902432 CC	NA	NA	NA	NA	NA	NA
		rs1902432 TT+TC	0.065	2.02 (0.96–4.27)	0.603	1.29 (0.49–3.37)	0.011	2.93 (1.28–6.70)
rs4573233 interacted with rs2632159	rs4573233 AA+GA vs GG	rs2632159 CC	0.547	0.85 (0.51–1.44)	NA	NA	NA	NA
		rs2632159 TT+TC	0.788	1.06 (0.70–1.61)	0.441	1.15 (0.81–1.64)	0.820	0.96 (0.67–1.40)
	rs2632159 CC vs TT+TC	rs4573233 AA+GA	0.406	1.23 (0.76–1.98)	0.200	1.45 (0.82–2.57)	0.991	1.00 (0.55–1.83)
		rs4573233 GG	0.063	1.55 (0.98–2.45)	0.101	1.57 (0.92–2.69)	0.141	1.52 (0.87–2.66)
rs710885 interacted with rs2632159	rs710885 GG+TG vs TT	rs2632159 CC	0.266	1.34 (0.80–2.23)	0.310	0.16 (0.01–5.49)	0.195	0.11 (0.00–3.09)
		rs2632159 TT+TC	0.570	0.58 (0.09–3.77)	0.164	1.45 (0.86–2.44)	0.310	1.34 (0.76–2.34)
	rs2632159 CC vs TT+TC	rs710885 GG+TG	0.189	3.84 (0.52–28.60)	0.516	1.95 (0.26–14.50)	NA	NA
		rs710885 TT	0.321	1.20 (0.84–1.72)	0.109	1.40 (0.93–2.13)	0.959	0.99 (0.62–1.56)
rs785005 interacted with rs2632159	rs785005 AA+GA vs GG	rs2632159 CC	0.672	0.89 (0.53–1.51)	NA	NA	NA	NA
		rs2632159 TT+TC	0.643	1.09 (0.76–1.55)	0.496	1.13 (0.80–1.59)	0.425	0.87 (0.61–1.23)
	rs2632159 CC vs TT+TC	rs785005 AA+GA	0.390	1.22 (0.77–1.94)	0.388	1.27 (0.74–2.16)	0.590	1.17 (0.66–2.10)
		rs785005 GG	0.051	1.55 (1.00–2.40)	0.008	2.01 (1.21–3.28)	0.540	1.18 (0.70–1.98)

Terms in bold represent significant results (P<0.05). All tests were adjusted by age and gender. Statistically significant associations were highlighted in bold (P<0.05). Abbreviations: CON, controls; CRC, colorectal cancer.