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. 2019 Jul 9;10:1576. doi: 10.3389/fmicb.2019.01576

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Copyright © 2019 Metzler-Zebeli, Siegerstetter, Magowan, Lawlor, O′Connell and Zebeli.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Circos plots of horizontal sparse partial least squares-discriminant analysis displaying correlations between the identified best discriminant operational taxonomic units (OTUs), short-chain fatty acids (SCFA, n = 5) and expression levels of target genes for component 1 and component 2 in the jejunum and ceca. Correlations for component 1 (comp) 1 (A) and 2 (B) in jejunum (OTUs, n = 8; SCFA, n = 2; genes, n = 5). Correlations for comp 1 (C) and 2 (D) in ceca (OTUs, n = 20; SCFA, n = 2; genes, n = 5). Positive and negative correlations (| r| > 0.7) are displayed by red and blue links, respectively. Relative abundance of bacterial OTUs > 0.01% of all reads. GLUT2, glucose transporter 2; IL, interleukin; MCT1, monocarboxylate transporter 1; OCLN, occludin; SGLT1, sodium-dependent glucose transporter 1; SMCT, sodium/monocarboxylate transporter; TGF1B, transforming growth factor beta-1; TLR, toll-like receptor; TNFA, tumor-necrosis factor alpha; ZO1, zonula occludens. The taxonomic identification of the most influential OTUs can be found in Supplementary Table S8.