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The structure of TEM-1 in apo (blue), reactant (green) and product (red) states. Ω loop (residues 163–180), helix 12 (residues 272–288), residues 102–108, and residues 213–220 are highlighted in each state with same colors. Also key residues Gln39, Thr269, Ser70, Lys73, Tyr105, and Asn132 are labeled. The ligand penicillin-G molecule is represented as green transparent surface.
