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. 2019 Jul 9;10:1469. doi: 10.3389/fimmu.2019.01469

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Copyright © 2019 Tammaro, Scantlebery, Rampanelli, Borrelli, Claessen, Butter, Soriani, Colonna, Leemans, Dessing and Florquin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TREM-1 signaling modulates senescence in TECs. (A) FACS analysis of senescence- associated β-galactosidase (SA-βgal) assay by C₁₂FDG incorporation in WT primary TECs stimulated with isotype control (CTR) and 10 μg/ml TREM-1 agonistic antibody (mTREM-1), during re-oxygenation conditions (24 h) (N = 5/6 animals per group). (B-C) Relative expression of p21 (cdkn1a) and Myd88 genes in WT TECs in CTR and mTREM-1 conditions, during reoxygenation. (D) Transcript expression of SASP-components such as pro-inflammatory (Il6, Il1a, Il1b) and (E) profibrotic genes (Tgfb, Ctgf, and Vegf) in WT TECs under re-oxygenation conditions stimulated with isotype control and mTREM-1 (N = 5–6 animals/group). All data are expressed as mean ± SEM and the unpaired t-test was used to determine statistical differences. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001.