Table 2.
Expression changes of shared genes in distinct expression datasets for Alzheimer's disease (AD) and ischemic stroke (IS)
| Gene | AD | IS | |||
|---|---|---|---|---|---|
| GSE44770 | GSE48350 | GSE55260 | GSE16561 | GSE70841 | |
| PFC | Hippocampus | Brain | Peripheral blood | Spleen | |
| ZYX | 2.41E−01 | 2.13E−01 | 8.43E−04 | 3.38E−04 | 8.08E−02 |
| EPHA1 | 6.12E−01 | 4.26E−02 | 9.48E−01 | 1.22E−03 | 9.23E−01 |
| EFTUD1 | 2.48E−01 | 4.15E−02 | 4.79E−02 | 5.31E−02 | 8.60E−02 |
| MS4A4A | 1.08E−24 | 3.87E−03** | — | 2.73E−05 | 1.57E−05 * |
| YDJC | — | 1.14E−04 | 7.58E−03 | 2.17E−01 | 4.61E−01 |
| UBE2L3 | 3.24E−20 | 4.45E−01 | 7.32E−01 | 5.68E−02 | 1.83E−03 |
| PABPC1 | 1.90E−11 | 2.99E−04 | 4.17E−05 * | 7.40E−02 | 5.27E−01 |
| RRN3P1 | — | 2.69E−01 | — | — | — |
| FAM154B | — | 3.14E−01 | 5.54E−02 | 8.80E−01 | 2.55E−01 |
| SLC16A5 | 4.93E−10 | 3.15E−01 | 1.16E−01 | 3.47E−02 | — |
| HECTD4 | 8.74E−16 | 5.17E−05 | — | — | — |
| ANKHD1 ‐ EIF4EBP3 | 4.30E−01 | 2.05E−01 | 9.75E−02 | 4.15E−02 | — |
| PINX1 | 2.46E−04 | 3.13E−01 | 2.03E−01 | 8.44E−01 | — |
| SLC2A11 | 1.41E−11 | 5.39E−03 | — | 2.55E−03 | — |
| OAS2 | 1.13E−01 | 1.46E−01 | 1.29E−01 | 2.04E−01 | — |
| TREM2 | 6.80E−20 | 1.34E−01 | 9.29E−06 * | 5.37E−01 | 7.10E−01 |
| Significance threshold | 3.85E−03 | 3.13E−03 | 3.85E−03 | 3.57E−03 | 5.56E−03 |
GEO accession, GSE44772, GSE48350, GSE55260, GSE16561 and GSE70841; PFC, dorsolateral prefrontal cortex; “—”, (no data) meant that the transcripts of this gene did not exist in corresponding datasets. Bolded P‐values of genes achieved Bonferroni‐corrected significance, adjusted for the number of shared genes present in each expression dataset (0.05/n, n ≤ 16).
*
Gene expression level showing more than 2 folds upregulation or downregulation compared to controls.
**
Genes near the significance threshold.