Figure 4.
Prophylaxis Effect of LX/IL-24-Infected Tumor Cells
(A) Mice were immunized with irradiated B16-F10, irradiated B16-F10 infected with LX/RFP, or irradiated B16-F10 infected with LX/IL-24 twice with 1-week intervals, respectively, then mice were challenged with 1 × 105 B16-F10 cells. (B) Mice were immunized with irradiated EL-4, irradiated EL-4 infected with LX/RFP, or irradiated EL-4 infected with LX/IL-24 twice with 1-week intervals, respectively, then mice were challenged with 1 × 105 EL-4 cells. (C) Mice were immunized with irradiated B16-F10 or irradiated B16-F10 infected with LX/IL-24, and challenged with EL-4 cells. The tumor volumes were monitored. The experiments were performed with five mice per group. *p < 0.05 and **p < 0.01.