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. 2019 Jul 9;13:701. doi: 10.3389/fnins.2019.00701

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Copyright © 2019 Zhan, Li, Yang, Feng, Zhang, Zhang, Zhao and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of combination treatment with XSEC and EE on the tissue loss and injury in MCAO rats. (A) Schematic diagram of the ischemic brain. The red region represents infarct area. The green square represents peri-ischemic cortex region and orange for striatum. (B) Typical 3D reconstruction images of cystic tissue were achieved by 3D Slicer software (red represented the cystic volume). (C) Representative T2 maps of bregma –0.80 mm from various groups. Quantitative analysis of (D) cystic volume, (E) hemispheric parenchymal volume ratios (ipsilateral vs. contralateral). Data were presented as mean ± SEM, n = 8, ^###P < 0.001 vs. control; ^∗P < 0.05 and ^∗∗P < 0.01 vs. vehicle; ^∧P < 0.05 and ^∧∧P < 0.01 vs. XSEC+EE.