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. 2019 Jul 9;13:701. doi: 10.3389/fnins.2019.00701

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Copyright © 2019 Zhan, Li, Yang, Feng, Zhang, Zhang, Zhao and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of combination treatment with XSEC and EE on cerebral perfusion in MCAO rats. (A) Representative ASL raw data maps and CBF maps were obtained from various groups. (B) The analysis of result of the relative CBF in the ipsilateral cortex and striatum. (C) Representative axial MIP maps of MRA were obtained from various groups. The amplified ACA (1, 3) and ICA (2, 4) signal pictures were below. (D) Quantitative analysis of vascular signal intensity. ACA, anterior cerebral artery; MCA, middle cerebral artery; ICA, internal carotid artery; PCA, posterior cerebral artery. Data were presented as mean ± SEM, n = 8, ^###P < 0.001 vs. control; ^∗P < 0.05, ^∗∗P < 0.01, and ^∗^∗∗P < 0.001 vs. vehicle.