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. 2019 Jul 9;13:701. doi: 10.3389/fnins.2019.00701

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Copyright © 2019 Zhan, Li, Yang, Feng, Zhang, Zhang, Zhao and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of combination treatment with XSEC and EE on the neurobehavior function in MCAO rats. (A) Assessment of motor functions by beam walking. (B) Typical training traces of rats in hidden platform test (top panel) on second session of 4th day and typical traces in probe test (bottom panel). (C) Path length, (D) escape latency, and (E) swim speed of rats in the hidden platform test. (F) Percentage time spent by rats in the target quadrant in the probe trial. Data were presented as mean ± SEM, n = 9–11, ^#P < 0.05, ^##P < 0.01, and ^###P < 0.001 vs. control; ^∗P < 0.05, ^∗∗P < 0.01, and ^∗∗∗P < 0.001 vs. vehicle; ^∧P < 0.05 vs. XSEC+EE.