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. 2019 Jul 11;14:5135–5146. doi: 10.2147/IJN.S199974

Table 1.

Characteristics and antiangiogenic effects of nanoparticles

Nanoparticle Biosynthesis Chemical synthesis Mean size
(nm)
Shape In vitro
study
Dose In vivo study Dose Effect Reference
CO 75 Spherical HUVECs 1.25, 2.5, and 5 µg/mL Nude mice Matrigel plug 1.25, 2.5, and 5 µg/mL Antiangiogenic 9
Au 15 Spherical HUVECs 125 and 250 nM CAM 1,000 and 1,500 nM/egg Antiangiogenic 12
Ag 16 Spherical CAM 50 and 200 µg/mL Antiangiogenic 15
Ag 50 Spherical BRECs 500 nM C57BL/6 mice 500 nM Antiangiogenic 16
Ag 10 Spherical HUVECs 50, 100, 200, and 400 µg/mL Antiangiogenic 17
Au 20
100
Spherical
Spherical
HUVECs 16.60 pM C57BL/6 mice 16.60 pM Antiangiogenic 18
SiO2 20
100
Spherical
Spherical
TiO2 20 Monodisperse HRMECs 1.30 µg/mL C57BL/6 mice 1.30 µg/mL Antiangiogenic 19
Au HUVECs Antiangiogenic 20
HAP 20 Spherical HUVECs 50 and 100 µg/mL Antiangiogenic 21
80 Rod–like
UDD 6 Ultra
dispersal
GBM cell on CAM 200 µ/ML
500 µ/ML
Antiangiogenic 22
MW–RF 65 Unknown
Au 20 Unknown HUVECS 0.1, 1, and 10 µM C57BL/6 mice 10 µM Antiangiogenic 23
NCe 20 Crystal 5,10, and 20 Unknown Nude mice 0.1 mg/kg Antiangiogenic 24
Au 20 Unknown HRMECs 1 and 5 µM C57BL/6 mice 1 µM Antiangiogenic 25
SiNPs 57 Spherical HRMECs, 5 µg/mL C57BL/6 mice 10 µg/mL Antiangiogenic 26
Ag 13 Spherical Rat aortic ring model 200 and 300 µg/mL Antiangiogenic 27
ZnO 20 Spherical CAM 50 µg/mL Antiangiogenic 28
Au 14 Monodisperse CAM
Mouse, Matrigel model
1 µg/cam
10 µg/Matrigel
Antiangiogenic 29
Ag 20 Polydisperse
CNPs 63 Unknown Athymic Nude mice 60 and 90 mg/kg Antiangiogenic 30
ND 4 Spherical CAM 500 mg/L Antiangiogenic 31
MWNT 8 Nanotube Antiangiogenic
NG 4 Spherical No effect
GNS 7 Sheet No effect
C60 50 Spherical Angiogenic
Ag 50 Unknown BRECs 500 nM Antiangiogenic 32
Diamond 4 Unknown GBM cell on CAM 50 µg/mL Antiangiogenic 33
SiO2 25 Unknown HUVECs 2.5 nM No effect 34

Abbreviations: CAM, chorioallantoic membrane; HUVECs, human umbilical vein endothelial cells; BRECs, bioartificial renal epithelial cells; HAP, Hydroxyapatite; UDD, ultra dispersed detonation diamond; MW-RF, micowave-radiofrequency; NCe, nanoceria; SiNPs, silicate nanoparticles; GBM, glioblastoma; CNPs, chitosan nanoparticles; DN, diamond nanoparticle; MWNT, multiwall nanotubes; NG, graphite nanoparticles; GNS, graphene nanoparticles; C60, fullerenes nanoparticles.