. 2019 Apr 26;18:131–139. doi: 10.1016/j.ctro.2019.04.014

Table 3.

Changes in DCE MRI of salivary glands during the course of radiotherapy.

Author, year	OAR	Time point	Main findings
Cheng, 2013 [22]	PG	BL Mean 53d post-RT	Post-RT, PGs showed a sign. higher A (+87%), peak enhancement (+93%, in all patients higher than BL values), wash-in slope (+73%) and a sign. lower K_el (−57%). No sign. change in k₂₁ and TTP. Only peak enhancement with sign. positive correlation to dose. K_el and slope with sign. negative and TTP with sign. positive correlation to PSV.
Houweling, 2011 [23]	PG, SMG	BL 6w post-RT	Sign increase post-RT in v_e (+33%/+23%) and sign. decrease in k_ep (−16%/−24%) in PGs and SMGs, respectively. No sign. difference from BL to post-RT in k_trans and v_p.
Lee, 2011 [24]	PG	BL 3 m post-RT	Sign. increase in k_trans (+71%), v_e (+93%), v_p (+477%) post-RT.

BL: baseline, k₂₁: contrast exchange rate constant, k_el: elimination transfer rate, k_ep: flux rate constant, k_trans: volume transfer coefficient, m: month, OAR: organ at risk, PG: parotid gland, PSV: parotid sparing volume, defined as percentage of PG receiving < 25 Gy, RT: radiotherapy, sign.: significant, SMG: submandibular gland, TTP: time-to-peak, v_e: extravascular volume fraction, v_p: vascular plasma space, w: week.