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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Nature. 2019 May 29;570(7762):474–479. doi: 10.1038/s41586-019-1252-x

Figure 1. Growth dynamics and genetic changes in naturally progressing CLL.

Figure 1

a, Schema of diverse growth patterns observable in CLL samples. b, Illustrative patient white blood count (WBC) dynamics over the period between diagnosis and start of treatment. c, Putative CLL drivers detected by analysis of whole-exome sequencing (WES) analysis of pre-treatment serial samples from 21 patients, with assigned growth patterns, IGHV status. Cancer cell fractions (CCF) of mutations are indicated.