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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Nature. 2019 May 29;570(7762):474–479. doi: 10.1038/s41586-019-1252-x

Extended Data Figure 3. Clonal shifts and growth rates in untreated CLL patients.

Extended Data Figure 3

a, The increase in numbers of total (upper panel), clonal and subclonal drivers (middle and bottom panels) is associated with overall leukaemia growth patterns (Kruskal-Wallis test). b, A trend towards increased maximal change in the CCF of a driver event is observed between the first and last pre-treatment samples of a given patient based on growth pattern (Kruskal-Wallis). c, Upper panel: Probability for having a carrying capacity K of WBC < 109 cells/L (blue dots) for patients with logistic (LOG), indeterminate (IND) or exponential (EXP) growth patterns. Bottom panel: Growth rates (small circles) together with 70% credible intervals (lines) across the discovery and extension samples, ordered based on probability of logistic growth with samples classified as displaying logistic (LOG) growth, indeterminate growth (IND) or exponential growth.