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. 2019 May 17;12(2):75. doi: 10.3390/ph12020075

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Schematic representation of the cell envelope of Mycobacterium tuberculosis (adapted from [2]). The cell envelope of M. tuberculosis includes an inner cell membrane (CM), a network of peptidoglycan (PG) with covalently attached macromolecules: AG, PIM₂, PIM₆, LM, and Man-LAM; an outer membrane (OM) composed of mycolic acid (MA), attached to TDM, DAT, PAT, PDIM, and SL-1; and an outmost layer of polysaccharides and proteins. AG: arabinogalactan; DAT: diacyltrehalose; LM: lipomannan; Man-LAM: mannose-capped lipoarabinomannan; PAT: poliacyltrehalose; PDIM: phthiocerol dimycocerosate; PIM₂: phospho-myo-inositol-dimannoside; PIM₆: phospho-myo-inositol-hexamannoside; MmpL: mycobacterial membrane protein large; TDM: trehalose dimycolate; SL-1: sulphoglycolipid.