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. 2019 Jun 15;11(6):282. doi: 10.3390/pharmaceutics11060282

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Blood compatibility of curcumin-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (CUR-NP), unloaded PLGA nanoparticles (NP) or free curcumin: (A) haemolysis assay and (B) aPTT test were performed. Where applicable, curcumin was used at a concentration of 0.1 mg/mL. Blank represents erythrocytes in the haemolysis assay and blood plasma in the aPTT test, respectively. Triton X-100 was used as positive control in (A) and is considered as 100% haemolysis. All samples were measured in triplicates (n = 9, independent formulations) and results are expressed as means ± SD. Dotted lines indicate the tolerance/threshold limits.