Table 2.
Incidence of adverse drug reactions (ADR)
| ≥75 years (n=31) | <75 years (n=89) | p-value | |||
|---|---|---|---|---|---|
| No, % | Grade (1/2/3/4–5) |
No, % | Grade (1/2/3/4–5) |
||
| Any ADR | 27 (87) | - | 63 (71) | - | 0.092 |
| Any gastrointestinal disorders | 24 (77) | - | 40 (45) | - | 0.002 |
| Anorexia | 20 (65) | 9/10/1/0 | 32 (36) | 18/13/1/0 | 0.007 |
| Dyspepsia | 4 (13) | 4/0/0/0 | 12 (13) | 10/2/0/0 | 1.0 |
| Gastroesophageal reflux disease | 5 (16) | 1/4/0/0 | 3 (3.4) | 3/0/0/0 | 0.027 |
| Nausea | 1 (3.2) | 1/0/0/0 | 8 (9.0) | 2/6/0/0 | 0.44 |
| Constipation | 1 (3.2) | 1/0/0/0 | 0 | - | 0.26 |
| Photosensitivity/Rash | 6 (19) | 4/2/0/0 | 19 (21) | 14/5/0/0 | 1.0 |
| Dizziness | 2 (6.5) | 2/0/0/0 | 9 (10) | 8/1/0/0 | 0.73 |
| Fatigue | 3 (9.7) | 3/0/0/0 | 6 (6.8) | 5/1/0/0 | 0.69 |
| Hepatic dysfunction | 1 (3.2) | 1/0/0/0 | 7 (7.9) | 6/1/0/0 | 0.68 |
| Dysgeusia | 0 | - | 3 (3.3) | 2/1/0/0 | 0.57 |
| Mucositis oral | 0 | - | 2 (2.2) | 1/1/0/0 | 1.0 |
| Cough | 0 | - | 1 (1.1) | 1/0/0/0 | 1.0 |
| Myalgia | 0 | - | 1 (1.1) | 0/1/0/0 | 1.0 |
| Arthralgia | 0 | - | 1 (1.1) | 0/1/0/0 | 1.0 |
| Headache | 0 | - | 1 (1.1) | 0/1/0/0 | 1.0 |
| Abdominal pain | 0 | - | 1 (1.1) | 0/1/0/0 | 1.0 |
| Somnolence | 0 | - | 1 (1.1) | 1/0/0/0 | 1.0 |
Note: Bold values indicate p<0.05.