Table 2.
Multivariate analysis of the prognostic factors by Cox regression showing variables with influence on the overall survival of the patients.
| Overall Survival | ||||||
|---|---|---|---|---|---|---|
| Parameter | B | SE | HR | 95%CI | p Value | |
| Lower | Upper | |||||
| Tumor grade (high) | 1.245 | 0.268 | 3.472 | 2.054 | 5.868 | <0.001 |
| Pathologic stage | ||||||
| pT1 | 0.844 | 0.325 | 2.326 | 1.230 | 4.401 | 0.009 |
| pT2 | 1.733 | 0.357 | 5.656 | 2.812 | 11.376 | <0.001 |
| Variant morphology (yes) | 0.106 | 0.192 | 1.112 | 0.764 | 1.620 | 0.580 |
| Carcinoma in situ (yes) | −0.163 | 0.242 | 0.850 | 0.529 | 1.365 | 0.501 |
| TGF-β1 (high) | 0.448 | 0.219 | 1.565 | 1.019 | 2.405 | 0.041 |
| Smad2 (high) | 0.052 | 0.204 | 1.053 | 0.705 | 1.572 | 0.800 |
| Smad4 (high) | −0.140 | 0.174 | 0.869 | 0.619 | 1.222 | 0.420 |