Table 4.

Protein expression of TRPV1 and TRPA1 in the animal colon (IHC: immunohistochemistry).

Protein	Location	Method	Model, Animal Species/Strain	Ref
TRPV1	intrinsic sensory neurons of the myenteric plexus-longitudinal muscle of ileum and colon	IHC	intact Sprague-Dawley rats and Dunkin-Hartley guinea pigs of both sexes	[52]
	mucosa, submucosal layers, myenteric plexus and mucosal layer of rectum, distal, transverse and proximal colon		male ddY mice	[50]
	immunopositive neuron fiber density is higher in the distal than the proximal colon		intact and 2.5% DSS-treated C57BL/6 mice colon	[51]
	enteric ganglia, epithelial cells of the distal colon, myenteric and submucosal plexuses, mucosal macrophages, leukocytes		male C57BL/6 mice	[33]
	membrane of resting CD4+ T cells	immunoblotting, flow cytometry, confocal microscopy	primary cell culture from C57BL/6 spleen	[55]
TRPA1	distal colonic epithelial cells, myenteric and submucosal plexuses, interstitial macrophages	IHC	male C57BL/6 mice	[33]
	myenteric and submucosal ganglia; surface epithelial cells of small and large intestines		intact C57BL/6 mice	[53]
	surface epithelium of middle colon		intact male Wistar rats	[54]
	membrane of resting CD4+ T cells	IHC, confocal microscopy	primary cell culture from C57BL/6 spleen	[37]